In this app, we investigate the effect of the Parkinson's Disease in the early olfactory system.
The antennal lobe is the first neuropil in the olfaction sensory pathway, which can be decomposed to ~50 subregions, called glomerulus. Each glomerulus consists of some 50 olfactory sensory neurons (input), and 3-5 projection neurons (output). Glomeruli are interconnected by over 100 local neurons. In total, the antennal lobe has about 2500 olfactory sensory neurons, 150 projection neurons, and 100 local neurons.
We first reconstructed the healthy model of the antennal lobe, emulated its response to input odorant, and visualized the ensemble response of projection neurons of each glomerulus in both biological view and interactive plot. Secondly, we hypothesized that the Parkinson's Disease causes the abnormal inhibitory neurotransmitter (GABA) release in the antennal lobe, and implemented a diseased model accordingly. The diseased model is emulated with the same input odorant as the healthy model, and its response is provide below alongside the result of the healthy model.